Dimethylamine → HCID 178482971, Verbindung

HRID 719504

Reaktionsgleichung

Reaktionsgleichung von HRID 719504
F[C:2]1[CH:7]=[C:6]([S:8]([CH3:11])(=[O:10])=[O:9])[CH:5]=[CH:4][C:3]=1[N:12]1[C:16]2=[N:17][CH:18]=[N:19][C:20]([OH:21])=[C:15]2[CH:14]=[N:13]1.[CH3:22][NH:23][CH3:24]>CS(C)=O>[CH3:22][N:23]([CH3:24])[C:2]1[CH:7]=[C:6]([S:8]([CH3:11])(=[O:10])=[O:9])[CH:5]=[CH:4][C:3]=1[N:12]1[C:16]2=[N:17][CH:18]=[N:19][C:20]([OH:21])=[C:15]2[CH:14]=[N:13]1

Komponenten

4

Edukt 2

HCID 674DimethylamineHCID 178504786HCID 178504786, Verbindung

Produkt 1

HCID 178482971HCID 178482971, VerbindungAusbeute 89,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 679Dimethyl SulfoxideLösungsmittel

Reaktionsbedingungen

Temperatur
120 °C

Versuchsvorschrift

1-(2-Fluoro-4-methanesulfonyl-phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-ol (0.520 g, 1.68 mmol) was dissolved in DMSO (3 mL) and dimethylamine (2M solution in THF) (4 mL, 150 mmol) was added. The mixture was heated at 120° C. for 15 h. The solvent was removed under reduced pressure and the crude was purified by HPLC, yielding 1-(2-dimethylamino-4-methanesulfonyl-phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-ol as an off-white solid (0.500 g, 89%). Exact mass calculated for C14H15N5O3S 333.09, found 334.4 (MH+, 100%).

Aufarbeitung

  1. customThe solvent was removed under reduced pressure
  2. customthe crude was purified by HPLC

Quellen und Nachweise

ORD-Eintrag
ord-161eeda7e80f4eba8db9bb3bb90bd04f
Quelldatensatz
uspto-grants-2006_11
Patentnummer
US07132426B2

Verknüpfte Notizen

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