Phenol → 3'-(2-Phenoxy-ethylsulfanylmethyl)-biphenyl-4-carboxylic acid ethyl ester

HRID 719711Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 719711
C(OC(C1C=C([C:12]2[CH:17]=[CH:16][C:15]([CH2:18][S:19][CH2:20][CH2:21][O:22][C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)=[CH:14][CH:13]=2)C=CC=1)=O)C.[CH2:29]([O:31][C:32]([C:34]1[CH:39]=[CH:38][C:37](C2C=CC=C(CSCCO)C=2)=[CH:36][CH:35]=1)=[O:33])[CH3:30].C1(O)C=CC=CC=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>C1COCC1>[CH2:29]([O:31][C:32]([C:34]1[CH:39]=[CH:38][C:37]([C:13]2[CH:12]=[CH:17][CH:16]=[C:15]([CH2:18][S:19][CH2:20][CH2:21][O:22][C:23]3[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=3)[CH:14]=2)=[CH:36][CH:35]=1)=[O:33])[CH3:30]

Komponenten

6

Edukt 4

HCID 996PhenolHCID 11776TriphenylphosphineHCID 586105864'-(2-Phenoxy-ethylsulfanylmethyl)-biphenyl-3-carboxylic acid ethyl esterHCID 586105983'-(2-Hydroxy-ethylsulfanylmethyl)-biphenyl-4-carboxylic acid ethyl ester

Produkt 1

HCID 586105883'-(2-Phenoxy-ethylsulfanylmethyl)-biphenyl-4-carboxylic acid ethyl ester

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

3′-(2-Phenoxy-ethylsulfanylmethyl)-biphenyl-4-carboxylic acid ethyl ester was synthesized as described for 4′-(2-phenoxy-ethylsulfanylmethyl)-biphenyl-3-carboxylic acid ethyl ester. 3′-(2-Hydroxy-ethylsulfanylmethyl)-biphenyl-4-carboxylic acid ethyl ester (1.95 g, 6.16 mmol, 1 eq.) in anhydrous THF was treated with phenol (0.75 g, 8.01 mmol, 1.3 eq.), triphenylphosphine (2.10 g, 8.01 mmol, 1.3 eq.), and diisopropyl azidocarboxylate (1.62 g, 8.01 mmol, 1.3 eq.). When complete, the reaction was worked up as described leaving an orange oil.

Aufarbeitung

  1. customas described leaving an orange oil

Quellen und Nachweise

ORD-Eintrag
ord-64fd9c67374e4cb3b627e5683e794f41
Quelldatensatz
uspto-grants-2006_11
Patentnummer
US07132456B2

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