Azobisisobutyronitrile → Ethyl 2'-bromomethyl-2-biphenylcarboxylate

HRID 719716

Reaktionsgleichung

Reaktionsgleichung von HRID 719716
C(OC(C1C=C(C2C=CC(C[Br:19])=CC=2)C=CC=1)=O)C.[CH2:20]([O:22][C:23]([C:25]1[C:26]([C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][C:32]=2[CH3:37])=[CH:27][CH:28]=[CH:29][CH:30]=1)=[O:24])[CH3:21].BrN1C(=O)CCC1=O.N(C(C)(C)C#N)=NC(C)(C)C#N>C(Cl)(Cl)(Cl)Cl>[CH2:20]([O:22][C:23]([C:25]1[C:26]([C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][C:32]=2[CH2:37][Br:19])=[CH:27][CH:28]=[CH:29][CH:30]=1)=[O:24])[CH3:21]

Komponenten

6

Edukt 4

HCID 6547AzobisisobutyronitrileHCID 67184N-bromobutanimideHCID 18325921[1,1'-Biphenyl]-2-carboxylic acid, 2'-methyl-, ethyl esterHCID 214642554'-Bromomethyl-biphenyl-3-carboxylic acid ethyl ester

Produkt 1

HCID 58610597Ethyl 2'-bromomethyl-2-biphenylcarboxylate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 5943Carbon TetrachlorideLösungsmittel

Versuchsvorschrift

2′-Bromomethyl-biphenyl-2-carboxylic acid ethyl ester was synthesized as described for 4′-bromomethyl-biphenyl-3-carboxylic acid ethyl ester. 2′-Methyl-biphenyl-2-carboxylic acid ethyl ester (10.35 g, 43.07 mmol, 1 eq.) in carbon tetrachloride was treated with N-bromosuccinimide (9.20 g, 51.68 mmol, 1.2 eq.) and 2,2′-azobisisobutyronitrile (0.35 g, 2.15 mmol, 5 mol %). When complete, the reaction was worked up as described leaving an orange oil.

Aufarbeitung

  1. customas described leaving an orange oil

Quellen und Nachweise

ORD-Eintrag
ord-bfe0762c9053428d9e2d601f66ec8932
Quelldatensatz
uspto-grants-2006_11
Patentnummer
US07132456B2

Verknüpfte Notizen

Wird geladen…