Thionyl Chloride → 2-(4-Chlorophenyl)-2-methylpropanoyl chloride

HRID 720035Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 720035
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([CH3:13])([CH3:12])[C:9](O)=[O:10])=[CH:4][CH:3]=1.S(Cl)([Cl:16])=O>ClCCl>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([CH3:13])([CH3:12])[C:9]([Cl:16])=[O:10])=[CH:4][CH:3]=1

Komponenten

4

Edukt 2

HCID 24386Thionyl Chloride2×HCID 804062-(4-Chlorophenyl)-2-methylpropionic acid

Produkt 1

HCID 135368632-(4-Chlorophenyl)-2-methylpropanoyl chloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Reaktionsbedingungen

Temperatur
40 °C

Versuchsvorschrift

2-(4-chlorophenyl)-2-methyl propionyl chloride was prepared as follows: To a flask containing 2-(4-chlorophenyl)-2-methyl propionic acid (15.0 g, 75.6 mmol) was added thionyl chloride (approx. 6 mL). Dichloromethane (20 mL) was then added before adding an additional portion of thionyl chloride (approx. 12 mL). The reaction was allowed to heat to 40° C. for two hours before cooling to room temperature and concentrating in vacuo (azeotroping with tetrahydrofuran). The resulting acid chloride was used in the following acylation step without further purification or characterization.

Aufarbeitung

  1. temperaturebefore cooling to room temperature
  2. concentrationconcentrating in vacuo (azeotroping with tetrahydrofuran)
  3. customThe resulting acid chloride was used in the following acylation step without further purification or characterization

Quellen und Nachweise

ORD-Eintrag
ord-ed833fa7d99b4c339465990fbf30bbf0
Quelldatensatz
uspto-grants-2006_11
Patentnummer
US07132551B2

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