Potassium Hydroxide → 5,6,7-Trimethoxy-1H-indole-2-carboxylic acid

HRID 720328

Reaktionsgleichung

Reaktionsgleichung von HRID 720328
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[C:10]([O:14][CH3:15])[C:11]=1[O:12][CH3:13])[NH:8][C:7]([C:16]([O:18]C)=[O:17])=[CH:6]2.[OH-].[K+]>CO>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[C:10]([O:14][CH3:15])[C:11]=1[O:12][CH3:13])[NH:8][C:7]([C:16]([OH:18])=[O:17])=[CH:6]2

Komponenten

4

Edukt 2

HCID 14797Potassium HydroxideHCID 4453649methyl 5,6,7-trimethoxy-1H-indole-2-carboxylate

Produkt 1

HCID 8210525,6,7-Trimethoxy-1H-indole-2-carboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

Methyl 5,6,7-trimethoxyindole-2-carboxylate (700 mg) was dissolved in methanol (13 mL), potassium hydroxide powder (450 mg) was added to the solution, and the mixture was stirred for 3 hours under reflux. After allowing the reaction mixture to cool, it was concentrated under reduced pressure, and water was added to the residue. The resultant water layer was washed with ether and then neutralized with diluted hydrochloric acid. Crystals deposited were collected by filtration and dried to obtain the title compound.

Aufarbeitung

  1. temperatureunder reflux
  2. temperatureto cool
  3. concentrationit was concentrated under reduced pressure, and water
  4. additionwas added to the residue
  5. washThe resultant water layer was washed with ether
  6. filtrationCrystals deposited were collected by filtration
  7. customdried

Quellen und Nachweise

ORD-Eintrag
ord-ef47eda3e0f746f9ab94ee01fb7f597b
Quelldatensatz
uspto-grants-2006_11
Patentnummer
US07135473B2

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