3-Bromopyridine → HCID 86591298, Verbindung

Reaktionsgleichung

Br[C:2]1[CH:3]=[N:4][CH:5]=[CH:6][CH:7]=1.[O:8]=[C:9]1[C@@H:16]2[C@@H:12]([CH2:13][N:14]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH2:15]2)[CH2:11][CH2:10]1>>[OH:8][C:9]1([C:2]2[CH:3]=[N:4][CH:5]=[CH:6][CH:7]=2)[C@@H:16]2[C@@H:12]([CH2:13][N:14]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH2:15]2)[CH2:11][CH2:10]1

Komponenten

Edukt 2

HCID 122863-Bromopyridine

HCID 29948688rel-1,1-Dimethylethyl (3aR,6aS)-hexahydro-4-oxocyclopenta[c]pyrrole-2(1H)-carboxylate

Produkt 1

HCID 86591298HCID 86591298, VerbindungAusbeute 27 %

Versuchsvorschrift

3-Bromopyridine (4.36 g, 27.6 mmol) and the product from Example 44A (2.07 g, 9.19 mmol) were processed as described in Example 1E to afford the title compound (0.743 g, 27%). MS (DCI/NH3) m/z 305 (M+H)+

Quellen und Nachweise

ORD-Eintrag: ord-10ff8feac28343bcaf077713c7794a0e
Quelldatensatz: uspto-grants-2006_11
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US07135484B2

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