5-Bromo-2-chloropyridine → HCID 131726056, Verbindung
Reaktionsgleichung
Br[C:2]1[CH:3]=[CH:4][C:5]([Cl:8])=[N:6][CH:7]=1.[O:9]=[C:10]1[C@@H:17]2[C@@H:13]([CH2:14][N:15]([C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19])[CH2:16]2)[CH2:12][CH2:11]1>>[C:21]([O:20][C:18]([N:15]1[CH2:16][C@@H:17]2[C:10]([OH:9])([C:2]3[CH:7]=[N:6][C:5]([Cl:8])=[CH:4][CH:3]=3)[CH2:11][CH2:12][C@@H:13]2[CH2:14]1)=[O:19])([CH3:24])([CH3:22])[CH3:23]Komponenten
3
Versuchsvorschrift
5-Bromo-2-chloropyridine (1.82 g, 9.46 mmol) and the product from Example 44A (1.64 g, 7.28 mmol) were processed as described in Example 1E to afford the title compound (1.25 g, 51%). MS (DCI/NH3) m/z 339, 341 (M+H)+.
Quellen und Nachweise
- ORD-Eintrag
- ord-80ad559ef03945658b15798c061b31e5
- Quelldatensatz
- uspto-grants-2006_11