Trifluoroacetic acid → L-Glutamic Acid

HRID 72095

Reaktionsgleichung

Reaktionsgleichung von HRID 72095
[NH2:1][C@H:2]([C:12]([O:14]C(C)(C)C)=[O:13])[CH2:3][CH2:4][C:5](=[O:11])[O:6]C(C)(C)C.C(ON1C(=O)CCC1=O)(=O)CCCCCCCCCCCCCCC([O-])=O.[B-](F)(F)(F)F.CN(C(ON1C(=O)CCC1=O)=[N+](C)C)C.C(O)(C(F)(F)F)=O>>[NH2:1][C@H:2]([C:12]([OH:14])=[O:13])[CH2:3][CH2:4][C:5](=[O:6])[OH:11]

Komponenten

5

Edukt 4

HCID 6422Trifluoroacetic acidHCID 208637L-Glutamic acid di-tert-butyl esterHCID 98575222-(2,5-Dioxopyrrolidin-1-yl)-1,1,3,3-tetramethylisouronium tetrafluoroborateHCID 131727748Succinimidyl hexadecandioate

Produkt 1

HCID 33032L-Glutamic Acid

Versuchsvorschrift

This compound was prepared in analogy with example 4, via reaction of L-Glu(OtBu)-OtBu with succinimidyl hexadecandioate followed by activation with TSTU, coupling with Des(B30) human insulin and deprotection by TFA. LCMS 6130.8, calculated 6132.2.

Quellen und Nachweise

ORD-Eintrag
ord-8a8b5a6e191740d29489d0fdf6c12a18
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08828923B2

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