Potassium Carbonate → Dimethyl-[1-(3-methyl-4-nitrophenyl)pyrrolidin-3-yl]amine

HRID 72194

Reaktionsgleichung

Reaktionsgleichung von HRID 72194
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[C:4]([CH3:11])[CH:3]=1.[CH3:12][N:13]([CH3:19])[CH:14]1[CH2:18][CH2:17][NH:16][CH2:15]1.C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[CH3:12][N:13]([CH3:19])[CH:14]1[CH2:18][CH2:17][N:16]([C:2]2[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[C:4]([CH3:11])[CH:3]=2)[CH2:15]1

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 949565-Fluoro-2-nitrotolueneHCID 27585193-(Dimethylamino)pyrrolidine

Produkt 1

HCID 68977058Dimethyl-[1-(3-methyl-4-nitrophenyl)pyrrolidin-3-yl]amine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

A mixture of 4-fluoro-2-methyl-1-nitrobenzene (13.6 g), dimethylpyrrolidin-3-ylamine (10.0 g), potassium carbonate (12 g) and DMF (100 mL) was stirred at room temperature for 4 hours. The reaction mixture was partitioned between water and ethyl acetate. The organic phase was dried and concentrated. The product with the molecular weight of 249.32 (C13H19N3O2) was obtained in this way; MS (ESI): 250 (M+H+).

Aufarbeitung

  1. customThe reaction mixture was partitioned between water and ethyl acetate
  2. customThe organic phase was dried
  3. concentrationconcentrated
  4. customThe product with the molecular weight of 249.32 (C13H19N3O2) was obtained in this way

Quellen und Nachweise

ORD-Eintrag
ord-0875dc4f41854179839123d1593d5957
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08828991B2

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