Benzoyl isocyanate, 2-chloro-4-fluoro- → HCID 178488185, Verbindung

HRID 722201

Reaktionsgleichung

Reaktionsgleichung von HRID 722201
[Cl:1][C:2]1[CH:12]=[C:11]([F:13])[CH:10]=[CH:9][C:3]=1[C:4]([N:6]=[C:7]=[O:8])=[O:5].[CH3:14][O:15][C:16]1[CH:21]=[C:20]([C:22]2[NH:26][C:25]([CH3:27])=[N:24][N:23]=2)[CH:19]=[CH:18][C:17]=1[NH2:28]>C(#N)C>[Cl:1][C:2]1[CH:12]=[C:11]([F:13])[CH:10]=[CH:9][C:3]=1[C:4]([NH:6][C:7]([NH:28][C:17]1[CH:18]=[CH:19][C:20]([C:22]2[NH:26][C:25]([CH3:27])=[N:24][N:23]=2)=[CH:21][C:16]=1[O:15][CH3:14])=[O:8])=[O:5]

Komponenten

4

Edukt 2

HCID 11521269Benzoyl isocyanate, 2-chloro-4-fluoro-HCID 178488184HCID 178488184, Verbindung

Produkt 1

HCID 178488185HCID 178488185, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

The solution of equivalent amounts of 2-chloro-4-fluorobenzoyl isocyanate was added dropwise to the solution of 35 mg of 2-methoxy-4-(5-methyl-4H-[1,2,4]triazol-3-yl)phenylamine in 3 ml of acetonitrile and the mixture was stirred at room temperature for 30 minutes. The solid was then filtered off with suction, stirred with t-butyl methyl ether, filtered off with suction and dried under reduced pressure.

Aufarbeitung

  1. filtrationThe solid was then filtered off with suction
  2. stirringstirred with t-butyl methyl ether
  3. filtrationfiltered off with suction
  4. customdried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-4144f6acc56a4529a02386356894212a
Quelldatensatz
uspto-grants-2006_11
Patentnummer
US07138414B2

Verknüpfte Notizen

Wird geladen…