Methyl acetoacetate → 5-Methyl-2-(3-methyl-4-nitrophenyl)-1,2-dihydro-3H-pyrazol-3-one

HRID 722224Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 722224
[CH3:1][C:2]1[CH:3]=[C:4]([NH:11][NH2:12])[CH:5]=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9].[C:13](OC)(=[O:18])[CH2:14][C:15]([CH3:17])=O>C1(C)C=CC=CC=1>[CH3:17][C:15]1[NH:12][N:11]([C:4]2[CH:5]=[CH:6][C:7]([N+:8]([O-:10])=[O:9])=[C:2]([CH3:1])[CH:3]=2)[C:13](=[O:18])[CH:14]=1

Komponenten

4

Edukt 2

HCID 7757Methyl acetoacetateHCID 13158578(3-Methyl-4-nitrophenyl)hydrazine

Produkt 1

HCID 218838945-Methyl-2-(3-methyl-4-nitrophenyl)-1,2-dihydro-3H-pyrazol-3-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

The mixture of 500 mg of 3-methyl-4-nitrophenylhydrazine, 0.32 ml of methyl acetoacetate and 20 ml of toluene was heated to 100° C. for 8 hours. After cooling, the reaction mixture was concentrated under reduced pressure and the residue was stirred in t-butyl methyl ether. The solid was filtered off with suction and dried under reduced pressure.

Aufarbeitung

  1. temperatureAfter cooling
  2. concentrationthe reaction mixture was concentrated under reduced pressure
  3. filtrationThe solid was filtered off with suction
  4. customdried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-1d7534c20f0a472882f3e77a1f4f46aa
Quelldatensatz
uspto-grants-2006_11
Patentnummer
US07138414B2

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