Pyridine → N-(4-fluoro-3-nitrophenyl)benzamide

Temperatur

0 °C

To a solution of 4-fluoro-3-nitro aniline (1.00 g, 6.41 mmol) in anhydrous CH2Cl2 (25 ml) was added pyridine (1.52 g, 19.23 mmol) and the solution was cooled to 0° C. under argon. Benzoyl chloride (0.90 g, 6.41 mmol) was added slowly and the solution was then allowed to slowly warm to room temperature and stir for 24 h. The solution was poured into 1NHCl and the organic layer was separated. The aqueous layer was extracted 3× with ethyl acetate (50 ml). The combined organic layers were washed with saturated sodium bicarbonate, water, brine and dried over anhydrous magnesium sulfate. The solution was filtered and the solvent removed under reduced pressure. The residue was purified by flash chromatography, eluting with hexane/ethyl acetate (4:1) to give N-(4-fluoro-3-nitro-phenyl)-benzamide. (1.60 g, 96%)

1. temperatureto slowly warm to room temperature
2. additionThe solution was poured into 1NHCl and the organic layer
3. customwas separated
4. extractionThe aqueous layer was extracted 3× with ethyl acetate (50 ml)
5. washThe combined organic layers were washed with saturated sodium bicarbonate, water, brine
6. dry with materialdried over anhydrous magnesium sulfate
7. filtrationThe solution was filtered
8. customthe solvent removed under reduced pressure
9. customThe residue was purified by flash chromatography
10. washeluting with hexane/ethyl acetate (4:1)

ORD-Eintrag

ord-94c691eb4cd04ef2bfa11567dba72890

Quelldatensatz

uspto-grants-2006_11

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07138420B2