Propylamine → 2-(3-Nitro-6-propylaminophenyl)-5-fluorobenzoxazole

HRID 722589Notizen

Reaktionsgleichung

[N+:1]([C:4]1[CH:5]=[C:6]([C:11]2[O:12][C:13]3[CH:19]=[CH:18][C:17]([F:20])=[CH:16][C:14]=3[N:15]=2)[C:7](F)=[CH:8][CH:9]=1)([O-:3])=[O:2].[CH2:21]([NH2:24])[CH2:22][CH3:23]>>[N+:1]([C:4]1[CH:5]=[C:6]([C:11]2[O:12][C:13]3[CH:19]=[CH:18][C:17]([F:20])=[CH:16][C:14]=3[N:15]=2)[C:7]([NH:24][CH2:21][CH2:22][CH3:23])=[CH:8][CH:9]=1)([O-:3])=[O:2]

Komponenten

Edukt 2

HCID 7852Propylamine

HCID 218843392-(3-Nitro-6-fluorophenyl)-5-fluorobenzoxazole

Produkt 1

HCID 218844562-(3-Nitro-6-propylaminophenyl)-5-fluorobenzoxazole

Versuchsvorschrift

Prepared by the method of Example 54a), from 2-(3-nitro-6-fluorophenyl)-5-fluorobenzoxazole (221 mg, 0.8 mmol) and propylamine (328 μL, 4.0 mmol) the subtitle compound was obtained. The product was used directly in the next step without purification.

Quellen und Nachweise

ORD-Eintrag: ord-4b56c77c369a40a8b23d728901df1a4d
Quelldatensatz: uspto-grants-2006_11
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US07138425B2

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