Hydrochloric Acid → methyl 5-bromo-1H-indole-2-carboxylate

HRID 722775

Reaktionsgleichung

Reaktionsgleichung von HRID 722775
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([C:11]([OH:13])=[O:12])=[CH:5]2.Cl.[CH3:15]O>>[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([C:11]([O:13][CH3:15])=[O:12])=[CH:5]2

Komponenten

4

Edukt 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 2521375-Bromo-1H-indole-2-carboxylic acid

Produkt 1

HCID 914343methyl 5-bromo-1H-indole-2-carboxylate

Versuchsvorschrift

A solution of 5-Bromo-1H-indole-2-carboxylic acid (commercial, 10.0 g, 41.6 mmol) in methanol (200 ml) was cooled to 0° C. and saturated with HCl(g). The resulting solution was allowed to warm gradually to room temperature overnight. The solvent was removed in vacuo and the residue treated with 0.88 ammonia (500 ml). The resulting solution was extracted with dichloromethane (3-fold 150 ml) and the combined organics dried (magnesium sulphate) and the solvent removed in vacuo to give the required product as a colourless oil (8.35 g).

Aufarbeitung

  1. customThe solvent was removed in vacuo
  2. additionthe residue treated with 0.88 ammonia (500 ml)
  3. extractionThe resulting solution was extracted with dichloromethane (3-fold 150 ml)
  4. dry with materialthe combined organics dried (magnesium sulphate)
  5. customthe solvent removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-8189599a83054a6a8e67f3aeb8e2e22c
Quelldatensatz
uspto-grants-2006_11
Patentnummer
US07138527B2

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