4-(5-Tert-butoxy-biphenyl-3-sulfonyl)-5-methylsulfanyl-thiophene-2-carboxylic acid ethyl ester → 4-(5-Hydroxy-biphenyl-3-sulfonyl)-5-methylsulfanyl-thiophene-2-carboxylic acid ethyl ester

HRID 723042Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 723042
[CH2:1]([O:3][C:4]([C:6]1[S:7][C:8]([S:31][CH3:32])=[C:9]([S:11]([C:14]2[CH:15]=[C:16]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)[CH:17]=[C:18]([O:20]C(C)(C)C)[CH:19]=2)(=[O:13])=[O:12])[CH:10]=1)=[O:5])[CH3:2]>C(O)(C(F)(F)F)=O.C(Cl)Cl>[CH2:1]([O:3][C:4]([C:6]1[S:7][C:8]([S:31][CH3:32])=[C:9]([S:11]([C:14]2[CH:15]=[C:16]([C:25]3[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=3)[CH:17]=[C:18]([OH:20])[CH:19]=2)(=[O:13])=[O:12])[CH:10]=1)=[O:5])[CH3:2]

Komponenten

3

Edukt 1

HCID 695864274-(5-Tert-butoxy-biphenyl-3-sulfonyl)-5-methylsulfanyl-thiophene-2-carboxylic acid ethyl ester

Produkt 1

HCID 695866254-(5-Hydroxy-biphenyl-3-sulfonyl)-5-methylsulfanyl-thiophene-2-carboxylic acid ethyl esterAusbeute 100,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 21863450Trifluoroacetic acid methylene chlorideLösungsmittel

Versuchsvorschrift

4-(5-tert-butoxy-biphenyl-3-sulfonyl)-5-methylsulfanyl-thiophene-2-carboxylic acid ethyl ester (55 mg, 0.11 mmol) was dissolved in 1:1 TFA/DCM (10 mL) and stirring for 1 h. Removal of the solvent in vacuo yielded the title compound (48 mg, 98%), which was used without further purification.

Aufarbeitung

  1. customRemoval of the solvent in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-47a8920062b1476a97233c139d842ad9
Quelldatensatz
uspto-grants-2006_11
Patentnummer
US07138530B2

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