2-Chloro-3-iodo-5-nitropyridine → 5-Amino-2-chloro-3-iodopyridine
Reaktionsgleichung
[Cl:1][C:2]1[C:7]([I:8])=[CH:6][C:5]([N+:9]([O-])=O)=[CH:4][N:3]=1>[Fe]>[NH2:9][C:5]1[CH:6]=[C:7]([I:8])[C:2]([Cl:1])=[N:3][CH:4]=1Komponenten
3
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
2-Chloro-3-iodo-5-nitropyridine (0.25g, 0.88 mmol) was reacted with iron powder (0.25g, 4.4 mmol) in the manner described in example 762D. Removal of the solvent in vacuo gave compound 765C (0.172g, 77%), as a golden yellow solid. HPLC: 100% at 2.32 min(YMC S5 ODS column) eluting with 10–90% aqueous methanol containing 0.2% phosphoric acid over a 4 min gradient monitoring at 220 nm. MS (ES): m/z 255.03 [M+H]+.
Aufarbeitung
- customRemoval of the solvent in vacuo
Quellen und Nachweise
- ORD-Eintrag
- ord-295b686205bd400bb52d5482937c0595
- Quelldatensatz
- uspto-grants-2006_11
- Patentnummer
- US07141578B2
Notizen zur Reaktion
Wird geladen…