3-Fluorophenol → (R)-tert-butyl 2-((3-fluorophenoxy)methyl)pyrrolidine-1-carboxylate
Reaktionsgleichung
[OH:1][CH2:2][C@H:3]1[CH2:7][CH2:6][CH2:5][N:4]1[C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9].[F:15][C:16]1[CH:17]=[C:18](O)[CH:19]=[CH:20][CH:21]=1>>[F:15][C:16]1[CH:21]=[C:20]([CH:19]=[CH:18][CH:17]=1)[O:1][CH2:2][C@H:3]1[CH2:7][CH2:6][CH2:5][N:4]1[C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9]Komponenten
3
Versuchsvorschrift
The title compound (D42) (D021/047/1) (252.3 mg) was prepared according to the experimental procedure described in Description 40 starting from (R)-tert-butyl 2-(hydroxymethyl)pyrrolidine-1-carboxylate (D41) (200 mg, 0.993 mmol) and 3-Fluorophenol (0.089 ml, 0.993 mmol).
Quellen und Nachweise
- ORD-Eintrag
- ord-33455f0201f7472da779c13f49e16a74
- Quelldatensatz
- uspto-grants-2014_09