Hydrochloric Acid → 4-Amino-1-methylcyclohexanol hydrochloride

HRID 724265Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 724265
[ClH:1].[OH:2][C:3]1([CH3:17])[CH2:8][CH2:7][CH:6]([NH:9]C(=O)OC(C)(C)C)[CH2:5][CH2:4]1>O1CCOCC1>[ClH:1].[NH2:9][CH:6]1[CH2:7][CH2:8][C:3]([CH3:17])([OH:2])[CH2:4][CH2:5]1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 21877240cis-4-(Boc-amino)-1-methylcyclohexanol

Produkt 1

HCID 218771344-Amino-1-methylcyclohexanol hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel2×

Versuchsvorschrift

4M Hydrochloric acid in dioxan (20 ml, 80 mmol) was added to a solution of the less polar diastereoisomer of tert-butyl 4-hydroxy-4-methylcyclohexylcarbamate (610 mg, 2.66 mmol) in dioxan (5 ml). The mixture was stirred for 3 h then the solvent was removed under reduced pressure and the residue dried in vacuo to afford a single diastereoisomer of 4-amino-1-methylcyclohexanol hydrochloride (625 mg) as a gum.

Aufarbeitung

  1. customthe solvent was removed under reduced pressure
  2. customthe residue dried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-084990a7dea645ec81b88c20e4f76c6d
Quelldatensatz
uspto-grants-2006_11
Patentnummer
US07141586B2

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