Lawesson's reagent → {2-[(6-Nitro-1h-indole-2-carbothioyl)amino]ethyl}carbamic acid tert-butyl ester
Reaktionsgleichung
[C:1]([O:5][C:6](=[O:25])[NH:7][CH2:8][CH2:9][NH:10][C:11]([C:13]1[NH:14][C:15]2[C:20]([CH:21]=1)=[CH:19][CH:18]=[C:17]([N+:22]([O-:24])=[O:23])[CH:16]=2)=O)([CH3:4])([CH3:3])[CH3:2].COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:35])=CC=1>C1(C)C=CC=CC=1>[C:1]([O:5][C:6](=[O:25])[NH:7][CH2:8][CH2:9][NH:10][C:11]([C:13]1[NH:14][C:15]2[C:20]([CH:21]=1)=[CH:19][CH:18]=[C:17]([N+:22]([O-:24])=[O:23])[CH:16]=2)=[S:35])([CH3:4])([CH3:3])[CH3:2]Komponenten
4
Versuchsvorschrift
To a suspension of 35 in toluene is added Lawesson's Reagent. The suspension is heated at reflux while stirring for 1 h. The reaction mixture is cooled over ice to precipitate the product. The product is then filtered, washed with hexane, and dried to give 156.