HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
3,4-Difluorophenol → 5-Chloro-2-(3-(3,4-difluorophenoxy)azetidin-1-yl)nicotinic acid
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 3,4-Difluorophenol | HCID 75927 | — |
| Edukt | Methyl 5-chloro-2-(3-((methylsulfonyl)oxy)azetidin-1-yl)nicotinate | HCID 86697874 | — |
| Produkt | 5-Chloro-2-(3-(3,4-difluorophenoxy)azetidin-1-yl)nicotinic acid | HCID 67958520 | 89,9% |
Reaktionsschritte
The title compound (D109) (87 mg) was prepared according to the experimental procedure described in Description 103A starting from methyl 5-chloro-2-(3-((methylsulfonyl)oxy)azetidin-1-yl)nicotinate (D63) (100 mg, 0.311 mmol) and 3,4-Difluorophenol (36.87 mg, 0.284 mmol).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08828987B2 |
| Quelldatensatz | uspto-grants-2014_09 |
| ORD ID | ord-c5af9a5393f64c708a00179f31e6aee7 |
| Quellennotiz | uspto-grants-2014_09 |