HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
4-Fluoro-3-(trifluoromethyl)phenol → 2-(3-(4-Fluoro-3-(trifluoromethyl)phenoxy)azetidin-1-yl)-5-(trifluoromethyl)nicotinic acid
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 4-Fluoro-3-(trifluoromethyl)phenol | HCID 601854 | — |
| Edukt | Methyl 2-(3-((methylsulfonyl)oxy)azetidin-1-yl)-5-(trifluoromethyl)nicotinate | HCID 86697871 | — |
| Produkt | 2-(3-(4-Fluoro-3-(trifluoromethyl)phenoxy)azetidin-1-yl)-5-(trifluoromethyl)nicotinic acid | HCID 86697875 | 98,7% |
Reaktionsschritte
The title compound (D125) (108 mg) was prepared according to the experimental procedure described in Description 103A starting from methyl 2-(3-((methylsulfonyl)oxy)azetidin-1-yl)-5-(trifluoromethyl)nicotinate (D68) (100 mg, 0.258 mmol) and 4-Fluoro-3-(trifluoromethyl)phenol (60.98 mg, 0.338 mmol).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08828987B2 |
| Quelldatensatz | uspto-grants-2014_09 |
| ORD ID | ord-79e437b0e96046e6aff8e2a56f024a1e |
| Quellennotiz | uspto-grants-2014_09 |