HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
3,4-Difluorophenol → 2-(3-(3,4-Difluorophenoxy)azetidin-1-yl)-5-(trifluoromethyl)nicotinic acid
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 3,4-Difluorophenol | HCID 75927 | — |
| Edukt | Methyl 2-(3-((methylsulfonyl)oxy)azetidin-1-yl)-5-(trifluoromethyl)nicotinate | HCID 86697871 | — |
| Produkt | 2-(3-(3,4-Difluorophenoxy)azetidin-1-yl)-5-(trifluoromethyl)nicotinic acid | HCID 67958244 | 103,6% |
Reaktionsschritte
The title compound (D128) (100 mg) was prepared according to the experimental procedure described in Description 103A starting from methyl 2-(3-((methylsulfonyl)oxy)azetidin-1-yl)-5-(trifluoromethyl)nicotinate (D68) (100 mg, 0.258 mmol) and 3,4-Difluorophenol (44.06 mg, 0.338 mmol).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08828987B2 |
| Quelldatensatz | uspto-grants-2014_09 |
| ORD ID | ord-fad1ebcbe7ba41e297cb888617862a54 |
| Quellennotiz | uspto-grants-2014_09 |