Methyl 4-(1-aminocyclopropyl)benzoate hydrochloride → Methyl 4-(1-(5-(trifluoromethyl)-2-(3-((6-(trifluoromethyl) pyridin-2-yl)oxy)azetidin-1-yl)nicotinamido)cyclopropyl)benzoate

HRID 72523

Reaktionsgleichung

Reaktionsgleichung von HRID 72523
[F:1][C:2]([F:28])([F:27])[C:3]1[CH:4]=[N:5][C:6]([N:12]2[CH2:15][CH:14]([O:16][C:17]3[CH:22]=[CH:21][CH:20]=[C:19]([C:23]([F:26])([F:25])[F:24])[N:18]=3)[CH2:13]2)=[C:7]([CH:11]=1)[C:8](O)=[O:9].Cl.[NH2:30][C:31]1([C:34]2[CH:43]=[CH:42][C:37]([C:38]([O:40][CH3:41])=[O:39])=[CH:36][CH:35]=2)[CH2:33][CH2:32]1>>[F:28][C:2]([F:1])([F:27])[C:3]1[CH:4]=[N:5][C:6]([N:12]2[CH2:15][CH:14]([O:16][C:17]3[CH:22]=[CH:21][CH:20]=[C:19]([C:23]([F:24])([F:25])[F:26])[N:18]=3)[CH2:13]2)=[C:7]([CH:11]=1)[C:8]([NH:30][C:31]1([C:34]2[CH:43]=[CH:42][C:37]([C:38]([O:40][CH3:41])=[O:39])=[CH:36][CH:35]=2)[CH2:33][CH2:32]1)=[O:9]

Komponenten

3

Edukt 2

HCID 66824369Methyl 4-(1-aminocyclopropyl)benzoate hydrochlorideHCID 866978775-(Trifluoromethyl)-2-(3-((6-(trifluoromethyl)pyridin-2-yl)oxy)azetidin-1-yl)nicotinic acid

Produkt 1

HCID 86697881Methyl 4-(1-(5-(trifluoromethyl)-2-(3-((6-(trifluoromethyl) pyridin-2-yl)oxy)azetidin-1-yl)nicotinamido)cyclopropyl)benzoateAusbeute 68,4 %

Versuchsvorschrift

The title compound (D181) (75 mg) was prepared according to the experimental procedure described in Description 144 starting from 5-(trifluoromethyl)-2-(3-((6-(trifluoromethyl)pyridin-2-yl)oxy)azetidin-1-yl)nicotinic acid (D130) (77 mg, 0.189 mmol) and methyl 4-(1-aminocyclopropyl)benzoate hydrochloride (D7) (43.04 mg, 0.189 mmol).

Quellen und Nachweise

ORD-Eintrag
ord-b1cc043b5ca74ef0b57e42026d14aeb7
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08828987B2

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