HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Methyl 4-(1-aminocyclopropyl)benzoate hydrochloride → Methyl 4-(1-(5-fluoro-2-(3-(3-fluorophenoxy)azetidin-1-yl)nicotinamido)cyclopropyl)benzoate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Methyl 4-(1-aminocyclopropyl)benzoate hydrochloride | HCID 66824369 | — |
| Edukt | 5-Fluoro-2-(3-(3-fluorophenoxy)azetidin-1-yl)nicotinic acid | HCID 67958637 | — |
| Produkt | Methyl 4-(1-(5-fluoro-2-(3-(3-fluorophenoxy)azetidin-1-yl)nicotinamido)cyclopropyl)benzoate | HCID 67958133 | 41,2% |
Reaktionsschritte
The title compound (D187) (45 mg) was prepared according to the experimental procedure described in Description 144 starting from 5-fluoro-2-(3-(3-fluorophenoxy)azetidin-1-yl)nicotinic acid (D132) (50 mg, 0.228 mmol) and methyl 4-(1-aminocyclopropyl)benzoate (D7) (52.04 mg, 0.228 mmol).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08828987B2 |
| Quelldatensatz | uspto-grants-2014_09 |
| ORD ID | ord-5a5c37ba9b1a4b50955c6eb0780e8755 |
| Quellennotiz | uspto-grants-2014_09 |