Tert-butyl 3-((3-fluorophenoxy)methyl)pyrrolidine-1-carboxylate → Methyl 4-(1-(5-chloro-2-(3-((3-fluorophenoxy)methyl)pyrrolidin-1-yl)nicotinamido)cyclopropyl)benzoate

HRID 72538

Reaktionsgleichung

Reaktionsgleichung von HRID 72538
[F:1][C:2]1[CH:3]=[C:4]([CH:19]=[CH:20][CH:21]=1)[O:5][CH2:6][CH:7]1[CH2:11][CH2:10][N:9]([C:12](OC(C)(C)C)=O)[CH2:8]1.ClC1[N:44]=[CH:43][C:42]([Cl:45])=[CH:41][C:24]=1[C:25]([NH:27][C:28]1([C:31]2[CH:40]=[CH:39][C:34]([C:35]([O:37][CH3:38])=[O:36])=[CH:33][CH:32]=2)[CH2:30][CH2:29]1)=[O:26]>>[Cl:45][C:42]1[CH:43]=[N:44][C:12]([N:9]2[CH2:10][CH2:11][CH:7]([CH2:6][O:5][C:4]3[CH:19]=[CH:20][CH:21]=[C:2]([F:1])[CH:3]=3)[CH2:8]2)=[C:24]([CH:41]=1)[C:25]([NH:27][C:28]1([C:31]2[CH:32]=[CH:33][C:34]([C:35]([O:37][CH3:38])=[O:36])=[CH:39][CH:40]=2)[CH2:30][CH2:29]1)=[O:26]

Komponenten

3

Edukt 2

HCID 24902824Tert-butyl 3-((3-fluorophenoxy)methyl)pyrrolidine-1-carboxylateHCID 86697873Methyl 4-(1-(2,5-dichloronicotinamido)cyclopropyl)benzoate

Produkt 1

HCID 67958339Methyl 4-(1-(5-chloro-2-(3-((3-fluorophenoxy)methyl)pyrrolidin-1-yl)nicotinamido)cyclopropyl)benzoateAusbeute 42,9 %

Versuchsvorschrift

The title compound (D200) (38 mg) was prepared according to the experimental procedure described in Description 160 starting from tert-butyl 3-((3-fluorophenoxy)methyl)pyrrolidine-1-carboxylate (D40) (100 mg, 0.338 mmol) and reacting in the second step with methyl 4-(1-(2,5-dichloronicotinamido)cyclopropyl)benzoate (D97) (61.8 mg, 0.169 mmol).

Quellen und Nachweise

ORD-Eintrag
ord-3c29f907b93249e18648fce3fe9ec4c5
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08828987B2

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