Iodine → HCID 12786936, Verbindung

HRID 725690Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 725690
[C:1]([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([Br:10])[N:5]=1)(=[O:3])[CH3:2].[I:11]I.C(O)(C)C.[N:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[I-:11].[Br:10][C:6]1[N:5]=[C:4]([C:1](=[O:3])[CH2:2][N+:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH:9]=[CH:8][CH:7]=1

Komponenten

5

Edukt 4

HCID 807IodineHCID 1049PyridineHCID 3776IsopropanolHCID 112985782-Acetyl-6-bromopyridine

Produkt 1

HCID 12786936HCID 12786936, Verbindung

Versuchsvorschrift

To a stirred solution of 2-acetyl-6-bromopyridine (100 g; 0.5 mole) in 600 mL pyridine was added iodine (127 g; 0.5 mole). The mixture was heated on a steam bath for 45 minutes, and the product crystallized on cooling. The solid was filtered and the light yellow crystalline cake was rinsed twice with methylene chloride. After drying, 183 g (90%) was obtained. MP 176°-178° C.; silica gel TLC system: 95acetone: 5 isopropanol.

Aufarbeitung

  1. temperatureThe mixture was heated on a steam bath for 45 minutes
  2. customthe product crystallized
  3. temperatureon cooling
  4. filtrationThe solid was filtered
  5. washthe light yellow crystalline cake was rinsed twice with methylene chloride
  6. customAfter drying
  7. custom183 g (90%) was obtained

Quellen und Nachweise

ORD-Eintrag
ord-fdae55a513b742c28bcefa581f5a4824
Quelldatensatz
uspto-grants-1998_01
Patentnummer
US05707603

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