Sodium Trifluoroacetate → 5-Trifluoromethyl-2-(di-n-propylamino)indan

HRID 725926Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 725926
Br[C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[CH2:7][CH:6]([N:11]([CH2:15][CH2:16][CH3:17])[CH2:12][CH2:13][CH3:14])[CH2:5]2.[F:18][C:19]([F:24])([F:23])C([O-])=O.[Na+]>CN1C=CC=CC1=O.C(OCC)(=O)C.[Cu]I>[F:18][C:19]([F:24])([F:23])[C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[CH2:7][CH:6]([N:11]([CH2:15][CH2:16][CH3:17])[CH2:12][CH2:13][CH3:14])[CH2:5]2

Komponenten

6

Edukt 2

HCID 517019Sodium TrifluoroacetateHCID 21221814(6-Bromo-indan-2-yl)-dipropyl-amine

Produkt 1

HCID 197102305-Trifluoromethyl-2-(di-n-propylamino)indan

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)KatalysatorHCID 8857Ethyl AcetateLösungsmittelHCID 127551-Methyl-2(1H)-pyridinoneLösungsmittel

Versuchsvorschrift

A solution of 5-bromo-2-(di-n-propylamino)indan (Example 11), sodium trifluoroacetate, and copper (I) iodide in N-methylpyridone is heated at 160° C. for 4 h under nitrogen (Chem Lett 1981, 1719). The reaction mixture is cooled to room temperature and diluted with ethyl acetate. The mixture is filtered through a layer of Celite pad and the filtrate is washed with water, brine, dried (MgSO4), filtered, and concentrated. The oil is purified by liquid chromatography to give the title compound as a yellow oil.

Aufarbeitung

  1. filtrationThe mixture is filtered through a layer of Celite pad
  2. washthe filtrate is washed with water, brine
  3. dry with materialdried (MgSO4)
  4. filtrationfiltered
  5. concentrationconcentrated
  6. customThe oil is purified by liquid chromatography

Quellen und Nachweise

ORD-Eintrag
ord-99091c0fa8264508863a54a7df4c6f40
Quelldatensatz
uspto-grants-1998_01
Patentnummer
US05708018

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