Carbamic chloride, N-methyl-N-phenyl- → N-methyl-N-phenyl-N'-(3-(1-methylpiperidin-4-yl)-1H-indol-5-yl)urea

HRID 725999

Reaktionsgleichung

Reaktionsgleichung von HRID 725999
[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH:11]1[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]1.[CH3:18][N:19]([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[C:20](Cl)=[O:21]>>[CH3:18][N:19]([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[C:20]([NH:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH:11]1[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]1)=[O:21]

Komponenten

3

Edukt 2

HCID 77969Carbamic chloride, N-methyl-N-phenyl-HCID 118312203-(1-Methylpiperidin-4-yl)-1h-indol-5-amine

Produkt 1

HCID 22611656N-methyl-N-phenyl-N'-(3-(1-methylpiperidin-4-yl)-1H-indol-5-yl)urea

Versuchsvorschrift

Beginning with 13.0 mg (0.056 mMol) 5-amino-3-(1-methyl-piperidin-4-yl)-1H-indole and 10.1 mg (0.059 mMol) N-methyl-N-phenyl carbamoyl chloride, 17.4 (86%) of the title compound were recovered.

Quellen und Nachweise

ORD-Eintrag
ord-2a0130195df1476ea0250984cc6a81cc
Quelldatensatz
uspto-grants-1998_01
Patentnummer
US05708008

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