Potassium Hydroxide → HCID 178420818, Verbindung

HRID 726251Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 726251
Cl.Cl[CH2:3][CH2:4][C:5]1[N:6]=[CH:7][NH:8][CH:9]=1.[SH:10][C:11]1[NH:12][CH:13]=[CH:14][N:15]=1.[OH-].[K+]>CC(O)C>[NH:8]1[CH:9]=[C:5]([CH2:4][CH2:3][S:10][C:11]2[NH:12][CH:13]=[CH:14][N:15]=2)[N:6]=[CH:7]1

Komponenten

5

Edukt 3

HCID 14797Potassium HydroxideHCID 1784785704-(2-chloroethyl)-1H-imidazole hydrochlorideHCID 178527877HCID 178527877, Verbindung

Produkt 1

HCID 178420818HCID 178420818, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3776IsopropanolLösungsmittel

Versuchsvorschrift

183 mg (1.1 mmol) of 4-(2-chloroethyl)-1H-imidazole hydrochloride, 110 mg (1 mmol) of 2-mercapto-1H-imidazole and 200 mg (3.26 mmol) of solid potassium hydroxide are brought to reflux in 10ml of 2-propanol for 4 h. The mixture is then evaporated and the semi-solid residue is chromatographed through silica gel, using a chloroform/methanol (5/1) mixture. The resulting product is treated with oxalic acid in ethanol to provide the title compound in the form of an oxalate salt, M.p.: 224-°226° C.

Aufarbeitung

  1. customThe mixture is then evaporated
  2. customthe semi-solid residue is chromatographed through silica gel
  3. additionThe resulting product is treated with oxalic acid in ethanol

Quellen und Nachweise

ORD-Eintrag
ord-2cb05886231e4834be9129f0fa3a733f
Quelldatensatz
uspto-grants-1998_01
Patentnummer
US05708171

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