Reaktionsgleichung
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[CH2:14][CH2:13][N:12]([CH2:15]/[CH:16]=[CH:17]/[CH2:18][NH2:19])[CH2:11][CH2:10]1.[O:20]1[C:24]2[CH:25]=[C:26]([C:29](Cl)=[O:30])[CH:27]=[CH:28][C:23]=2[NH:22][C:21]1=[O:32].C(=O)([O-])[O-].[Na+].[Na+]>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[CH2:10][CH2:11][N:12]([CH2:15]/[CH:16]=[CH:17]/[CH2:18][NH:19][C:29]([C:26]2[CH:27]=[CH:28][C:23]3[NH:22][C:21](=[O:32])[O:20][C:24]=3[CH:25]=2)=[O:30])[CH2:13][CH2:14]1Komponenten
4
Versuchsvorschrift
According to the method of Example 7, trans-4-[4-(2-methyloxyphenyl)piperazinyl]-2-buten-1-yl-amine and benzoxazolin-2-one-6-carbonyl chloride were subjected to acylation in the presence of sodium carbonate to obtain the product. Yield: 87.5%. mp: 200-202° C. 1HNMR (ppm, DMSO-d6) δ: 2.50 (m, 4H), 2.96 (s, br., 4H), 3.31 (m, 2H), 3.75 (s, 3H), 3.89 (t, 2H), 5.62-5.67 (m, 2H), 6.86 (m, 2H), 6.91 (m, 2H), 7.14 (d, J=8.2 Hz, 1H), 7.73-7.77 (m, 2H), 8.63 (t, J=5.6 Hz, 1H).
Aufarbeitung
- customto obtain the product
Quellen und Nachweise
- ORD-Eintrag
- ord-a994ecd3eef74b01bec51d632596988c
- Quelldatensatz
- uspto-grants-2014_09
- Patentnummer
- US08829001B2
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