Piperazine → 1-(5-Trifluoromethyl-pyridin-2-yl)-piperazine

HRID 72673

Reaktionsgleichung

Reaktionsgleichung von HRID 72673
[NH:1]1[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.Cl[C:8]1[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][N:9]=1>C1COCC1>[F:15][C:14]([F:17])([F:16])[C:11]1[CH:12]=[CH:13][C:8]([N:1]2[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]2)=[N:9][CH:10]=1

Komponenten

4

Edukt 2

HCID 4837PiperazineHCID 923422-Chloro-5-(trifluoromethyl)pyridine

Produkt 1

HCID 6676181-(5-Trifluoromethyl-pyridin-2-yl)-piperazine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

Piperazine (1.2 g, 13.77 mM) was heated with 2-chloro-5-(trifluoromethyl)pyridine (0.5 g, 2.75 mmol) in THF (2 mL) for 2 hours. Subsequently the reaction mixture was poured onto crushed ice and extracted with ethyl acetate. The organic layer was washed with sodium bicarbonate and evaporated to furnish the required product.

Aufarbeitung

  1. additionSubsequently the reaction mixture was poured
  2. customonto crushed ice
  3. extractionextracted with ethyl acetate
  4. washThe organic layer was washed with sodium bicarbonate
  5. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-2539442d428d4383a6d9b930dc5daea0
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08828999B2

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