Piperazine → HCID 18423149, Verbindung

HRID 72675Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 72675
[NH:1]1[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.Cl[C:8]1[N:13]=[C:12]([O:14][CH3:15])[N:11]=[C:10]([O:16][CH3:17])[CH:9]=1>C(#N)C>[CH3:15][O:14][C:12]1[N:11]=[C:10]([O:16][CH3:17])[CH:9]=[C:8]([N:1]2[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]2)[N:13]=1

Komponenten

4

Edukt 2

HCID 4837PiperazineHCID 806004-Chloro-2,6-dimethoxypyrimidine

Produkt 1

HCID 18423149HCID 18423149, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

Piperazine (1.23 g, 14.32 mmol) was treated with 6-chloro-2,4-dimethoxy pyrimidine (0.5 g, 2.86 mmol) in acetonitrile (5 mL) and the reaction mixture was stirred at room temperature for 6 hours. Subsequently the reaction mixture was poured onto ice-cold water (25 ml) and extracted with ethyl acetate (25 ml). The organic layer was washed with aqueous sodium bicarbonate solution and evaporated to furnish the required compound.

Aufarbeitung

  1. additionSubsequently the reaction mixture was poured onto ice-cold water (25 ml)
  2. extractionextracted with ethyl acetate (25 ml)
  3. washThe organic layer was washed with aqueous sodium bicarbonate solution
  4. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-8af2c11b57d54f988b7d70e12df7b2c8
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08828999B2

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