Piperazine → 1-(5-Nitropyridin-2-yl)piperazine

HRID 72677

Reaktionsgleichung

Reaktionsgleichung von HRID 72677
Br[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][N:3]=1.[NH:11]1[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1>O1CCCC1>[N+:8]([C:5]1[CH:6]=[CH:7][C:2]([N:11]2[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]2)=[N:3][CH:4]=1)([O-:10])=[O:9]

Komponenten

4

Edukt 2

HCID 4837PiperazineHCID 782402-Bromo-5-nitropyridine

Produkt 1

HCID 29287991-(5-Nitropyridin-2-yl)piperazine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

2-Bromo-5-nitropyridine (0.3 g, 1.48 mmol) was treated with piperazine (0.64 g, 7.89 mmol) in tetrahydrofuran (4 ml) and the reaction mixture was stirred for 30 minutes. Subsequently the reaction mixture was poured onto ice-cold water (25 ml) and extracted with ethyl acetate (25 ml). The organic layer was washed with brine and evaporated to furnish the product.

Aufarbeitung

  1. additionSubsequently the reaction mixture was poured onto ice-cold water (25 ml)
  2. extractionextracted with ethyl acetate (25 ml)
  3. washThe organic layer was washed with brine
  4. customevaporated
  5. customto furnish the product

Quellen und Nachweise

ORD-Eintrag
ord-f5dcf78513fb4a359bf8be3f6ed6cc51
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08828999B2

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