1-Phenethylamine, (+)- → (R)-N-tert-butyl-3,3-dimethyl-2-(1-phenylethylimino)-butyramide

HRID 726871

Reaktionsgleichung

Reaktionsgleichung von HRID 726871
[C:1]([NH:5][C:6](=[O:13])[C:7](=O)[C:8]([CH3:11])([CH3:10])[CH3:9])([CH3:4])([CH3:3])[CH3:2].[C:14]1([C@H:20]([NH2:22])[CH3:21])[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>>[C:1]([NH:5][C:6](=[O:13])[C:7](=[N:22][C@@H:20]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[CH3:21])[C:8]([CH3:11])([CH3:10])[CH3:9])([CH3:4])([CH3:3])[CH3:2]

Komponenten

3

Edukt 2

HCID 6431891-Phenethylamine, (+)-HCID 13355144N-tert-Butyl-3,3-dimethyl-2-oxobutanamide

Produkt 1

HCID 54448076(R)-N-tert-butyl-3,3-dimethyl-2-(1-phenylethylimino)-butyramideAusbeute 58,2 %

Versuchsvorschrift

The procedure described under l) was carried out using 7.5 g of N-tert-butyl-3,3-dimethyl-2-oxo-butyramide and 15 g of (R)-1-phenylethylamine. There were isolated 6.8 g (58%) of (R)-N-tert-butyl-3,3-dimethyl-2-(1-phenylethylimino)-butyramide of boiling point 120° at 0.2 mbar. [α]=+40.9 (c=1.0, CHCl3).

Quellen und Nachweise

ORD-Eintrag
ord-226a520cff7e4dce9cd8b645360985ee
Quelldatensatz
uspto-grants-1998_01
Patentnummer
US05710322

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