HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2,6-Dibromopyridine → 6-Bromo-N-(tetrahydro-2H-pyran-4-yl)pyridin-2-amine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 2,6-Dibromopyridine | HCID 12274 | — |
| Edukt | 4-Aminotetrahydropyran | HCID 419223 | — |
| Reagenz | Cesium carbonate | HCID 10796 | — |
| Katalysator | 1,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine) | HCID 636044 | — |
| Katalysator | Palladium (II) acetate | HCID 4144353 | — |
| Lösungsmittel | 1,4-Dioxane | HCID 31275 | — |
| Produkt | 6-Bromo-N-(tetrahydro-2H-pyran-4-yl)pyridin-2-amine | HCID 63962797 | 0% |
Reaktionsschritte
to 2,6-dibromopyridine (100 mg, 0.42 mmol), 4-Aminotetrahydropyran (42.7 mg, 0.42 mmol) in dioxane (3 mL) while bubbling N2 was added Xantphos (24.43 mg, 0.04 mmol), CS2CO3 (316 mg, 0.97 mmol) and palladium(II) acetate (9.48 mg, 0.04 mmol). This was heated in a microwave at 130 oC for 30 mins. A small peak corresponding to product was obseved. Discontinued
Herkunft & Nachweise
| Quelldatensatz | 750 AstraZeneca ELN dataset |
|---|---|
| ORD ID | ord-13cef69f8e724020954e5476c0d66794 |
| Quellennotiz | 750 AstraZeneca ELN dataset |