HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 72773Erstellt: 23. Oktober 2026
Piperidine → Ethyl 5-[(E)-2-ethoxycarbonylvinyl]-3-methyl-1H-pyrrole-2-carboxylate
https://huagongshe.com/de/reaction/72773
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Piperidine | HCID 8082 | — |
| Edukt | ethyl 5-formyl-3-methyl-1H-pyrrole-2-carboxylate | HCID 1113514 | — |
| Edukt | Propanedioic acid, monoethyl ester | HCID 3595298 | — |
| Lösungsmittel | Pyridine | HCID 1049 | — |
| Produkt | Ethyl 5-[(E)-2-ethoxycarbonylvinyl]-3-methyl-1H-pyrrole-2-carboxylate | HCID 59198650 | 47,7% |
Reaktionsschritte
Ethyl 5-formyl-3-methyl-1H-pyrrole-2-carboxyate 470 mg, monoethyl malonate 378 mg, piperidine 0.05 mL and pyridine 6 mL were mixed and stirred at 100° C. for 38 hours. Ice water was added to the reaction liquid and the precipitate was recovered by filtration. The precipitate was washed with water and dried in flowing air under heating to provide 311 mg of the title compound.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patentnummer | US08829000B2 |
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| Quelldatensatz | uspto-grants-2014_09 |
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| ORD ID | ord-fb2dddac9b4b492ab2f73cd7baa61606 |
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| Quellennotiz | uspto-grants-2014_09 |
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