Hydrochloric Acid → 2-(3,4-Bis(benzyloxy)phenyl)acetic acid

HRID 728073Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 728073
[OH-].[K+].[CH2:3]([O:10][C:11]1[CH:12]=[C:13]([CH2:25][C:26]([O:28]CC2C=CC=CC=2)=[O:27])[CH:14]=[CH:15][C:16]=1[O:17][CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.Cl>CO>[CH2:3]([O:10][C:11]1[CH:12]=[C:13]([CH2:25][C:26]([OH:28])=[O:27])[CH:14]=[CH:15][C:16]=1[O:17][CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 419522HCID 419522, Verbindung

Produkt 1

HCID 5618122-(3,4-Bis(benzyloxy)phenyl)acetic acidAusbeute 78,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

Potassium hydroxide (6.2 g) was added to a solution of benzyl 3,4-dibenzyloxyphenylacetate (16.0 g) in methanol (200 ml), followed by stirring at room temperature for 6 hours. The reaction mixture was adjusted to pH 4.0 with 5N hydrochloric acid solution. The solvent was distilled off and to the residue was added water. The precipitated crystal was collected by filtration, washed with water and dried to obtain as colorless crystal 3,4-dibenzyloxyphenylacetic acid (10.0 g).

Aufarbeitung

  1. distillationThe solvent was distilled off and to the residue
  2. additionwas added water
  3. filtrationThe precipitated crystal was collected by filtration
  4. washwashed with water
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-a73f8cf75ef24949afbfa02650c3f78c
Quelldatensatz
uspto-grants-1991_09
Patentnummer
US05047430

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