HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Methanol → 1-(2-Hydroxyethoxymethyl)-5-(3-trifluoroacetamido-1-propynyl)cytosine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Methanol | HCID 887 | — |
| Edukt | 2,2,2-trifluoro-N-(prop-2-yn-1-yl)acetamide | HCID 11094805 | — |
| Edukt | 1-(2-Hydroxyethoxymethyl)5-iodocytosine | HCID 19958007 | — |
| Lösungsmittel | Dichloromethane | HCID 6344 | — |
| Produkt | 1-(2-Hydroxyethoxymethyl)-5-(3-trifluoroacetamido-1-propynyl)cytosine | HCID 19958018 | 23% |
Reaktionsschritte
Iodide 68 (311 mg, 1.00 mmol) was coupled to N-propargyltrifluoroacetamide (43) according to the general procedure described in EXAMPLE 1C. Flash chromatography on silica gel (3×20 cm) with 5%, 10% and 20% methanol in dichlormethane afforded alkynylamino nucleotide 69 as a pale yellow foam (77.4 mg, 23%).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US05047519 |
| Quelldatensatz | uspto-grants-1991_09 |
| ORD ID | ord-bc6a53a4a1f749289624d16a20c24916 |
| Quellennotiz | uspto-grants-1991_09 |