Methyl iodide → 3-methyl-1-{4H,5H,6H,7H-thieno[3,2-c]pyridine-5-carbonyl}-1H-imidazol-3-ium iodide
Reaktionsgleichung
[CH3:1][I:2].[S:3]1[C:11]2[CH2:10][CH2:9][N:8]([C:12]([N:14]3[CH:18]=[CH:17][N:16]=[CH:15]3)=[O:13])[CH2:7][C:6]=2[CH:5]=[CH:4]1>C(#N)C>[I-:2].[S:3]1[C:11]2[CH2:10][CH2:9][N:8]([C:12]([N:14]3[CH:18]=[CH:17][N+:16]([CH3:1])=[CH:15]3)=[O:13])[CH2:7][C:6]=2[CH:5]=[CH:4]1Komponenten
4
Versuchsvorschrift
Methyl iodide (50 μL) is added to a solution of (6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)imidazol-1-yl-methanone (100 mg) in acetonitrile (5 mL) at room temperature. The solution is stirred for 5 h, before more methyl iodide (100 μL) is added. After stirring the solution for another 10 h, the solution is concentrated to give the crude title compound that is used without further purification.