Trimethyl phosphite → E-2-formylamino-4-ethyl-5-dimethylphosphono-3-pentenoic acid ethyl ester
Reaktionsgleichung
[CH2:1]([O:3][C:4](=[O:15])[CH:5]([NH:12][CH:13]=[O:14])[CH:6](O)[C:7]([CH2:9][CH3:10])=[CH2:8])[CH3:2].S(Br)(Br)=O.[P:20]([O:25]C)([O:23][CH3:24])[O:21][CH3:22]>>[CH2:1]([O:3][C:4](=[O:15])[CH:5]([NH:12][CH:13]=[O:14])/[CH:6]=[C:7](\[CH2:9][CH3:10])/[CH2:8][P:20]([O:23][CH3:24])([O:21][CH3:22])=[O:25])[CH3:2]Komponenten
4
Versuchsvorschrift
Reaction of the 2-formylamino-3-hydroxy-4-ethyl-4-pentenoic acid ethyl ester with thionyl bromide and subsequent treatment with trimethyl phosphite in a manner analogous to that described in Example 1 yields E-2-formylamino-4-ethyl-5-dimethylphosphono-3-pentenoic acid ethyl ester.