Methanol → Methyl 2-fluoro-4-hydroxybenzoate

Temperatur

40 °C

To a solution of 2-fluoro-4-hydroxy-benzoic acid (5.32 g, 34.1 mmol) in methanol (21 mL) was added thionyl chloride (4.86 g, 3 mL, 40.9 mmol) dropwise and the reaction mixture was stirred at 40° C. for 3 hours. The reaction mixture was concentrated in vacuo and diluted with DCM (100 mL) and washed with aqueous saturated NaHCO3 (2×50 mL) solution. The organics were separated and dried with MgSO4, filtered and concentrated in vacuo to give methyl 2-fluoro-4-hydroxy-benzoate (2.3 g, 40%). ESI-MS m/z calc. 170.1. Found 171.3 (M+1)+; Retention time: 0.84 minutes (3 min run).

1. concentrationThe reaction mixture was concentrated in vacuo
2. additiondiluted with DCM (100 mL)
3. washwashed with aqueous saturated NaHCO3 (2×50 mL) solution
4. customThe organics were separated
5. dry with materialdried with MgSO4
6. filtrationfiltered
7. concentrationconcentrated in vacuo

ORD-Eintrag

ord-f42e4f4d409d4b4daff3a9df8d97d428

Quelldatensatz

uspto-grants-2014_09

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08828996B2