Ammonia → 5-[4-(2-Bromo-5-fluorophenoxy)piperidin-1-yl]pyrazine-2-carboxamide

HRID 729452Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 729452
[Br:1][C:2]1[CH:24]=[CH:23][C:22]([F:25])=[CH:21][C:3]=1[O:4][CH:5]1[CH2:10][CH2:9][N:8]([C:11]2[N:12]=[CH:13][C:14]([C:17]([O:19]C)=O)=[N:15][CH:16]=2)[CH2:7][CH2:6]1.[NH3:26]>CO>[Br:1][C:2]1[CH:24]=[CH:23][C:22]([F:25])=[CH:21][C:3]=1[O:4][CH:5]1[CH2:10][CH2:9][N:8]([C:11]2[N:12]=[CH:13][C:14]([C:17]([NH2:26])=[O:19])=[N:15][CH:16]=2)[CH2:7][CH2:6]1

Komponenten

4

Edukt 2

HCID 222AmmoniaHCID 57832729Methyl 5-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]pyrazine-2-carboxylate

Produkt 1

HCID 690622895-[4-(2-Bromo-5-fluorophenoxy)piperidin-1-yl]pyrazine-2-carboxamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Reaktionsbedingungen

Temperatur
55 °C

Versuchsvorschrift

A methanol (30 mL) suspension of methyl 5-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]pyrazine-2-carboxylate from Step 3 (2.00 g, 4.87 mmol) in a sealed tube was saturated with ammonia gas at 0° C. The mixture was then heated in an oil bath at 55° C. for two days. The reaction mixture was cooled and evaporated. To the white solid residue was added ether followed by filtration to provide the title compound.

Aufarbeitung

  1. temperatureThe reaction mixture was cooled
  2. customevaporated
  3. additionTo the white solid residue was added ether
  4. filtrationfollowed by filtration

Quellen und Nachweise

ORD-Eintrag
ord-88ac595096ee454cb0c4f32141dd1f42
Quelldatensatz
uspto-grants-2009_09
Patentnummer
US07582633B2

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