Ammonia → HCID 45380634, Verbindung
Reaktionsgleichung
[Br:1][C:2]1[CH:22]=[CH:21][C:20]([F:23])=[CH:19][C:3]=1[O:4][CH:5]1[CH2:8][N:7]([C:9]2[N:10]=[CH:11][C:12]([C:15](OC)=[O:16])=[N:13][CH:14]=2)[CH2:6]1.[NH3:24]>CO>[Br:1][C:2]1[CH:22]=[CH:21][C:20]([F:23])=[CH:19][C:3]=1[O:4][CH:5]1[CH2:8][N:7]([C:9]2[N:10]=[CH:11][C:12]([C:15]([NH2:24])=[O:16])=[N:13][CH:14]=2)[CH2:6]1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 50 °C
Versuchsvorschrift
To methyl 5-[3-(2-bromo-5-fluorophenoxy)azetidin-1-yl]pyrazine-2-carboxylate (0.080 g, 2.1 mmol) in MeOH was bubbled ammonia and the mixture was heated at 50° C. After 2 d, the methanol was evaporated followed by the addition of ether. The solid was filtered to provide the title compound as a white solid.