1-(Chloromethyl)-2-fluoro-4-methoxybenzene → 6-Amino-2-[(2-fluoro-4-methoxybenzyl)thio]pyrimidin-4(3H)-one
Reaktionsgleichung
O.[NH2:2][C:3]1[CH:8]=[C:7]([OH:9])[N:6]=[C:5]([SH:10])[N:4]=1.[F:11][C:12]1[CH:19]=[C:18]([O:20][CH3:21])[CH:17]=[CH:16][C:13]=1[CH2:14]Cl>>[NH2:2][C:3]1[N:4]=[C:5]([S:10][CH2:14][C:13]2[CH:16]=[CH:17][C:18]([O:20][CH3:21])=[CH:19][C:12]=2[F:11])[NH:6][C:7](=[O:9])[CH:8]=1Komponenten
3
Versuchsvorschrift
The subtitle compound was prepared according to the procedure of Example 1 step i) treating 4-amino-6-hydroxy-2-mercaptopyrimidine monohydrate (1.86 g) with 2-fluoro-4-methoxybenzyl chloride (2.00 g) to afford the subtitle compound as a white solid. Yield: 2.64 g.
Aufarbeitung
- customThe subtitle compound was prepared
Quellen und Nachweise
- ORD-Eintrag
- ord-f0fdcecc0a0248ebbbf2df61c3445163
- Quelldatensatz
- uspto-grants-2009_09
- Patentnummer
- US07582644B2
Notizen zur Reaktion
Wird geladen…