Diethylamine → 5-Bromo-2-diethylamino-nicotinic acid

HRID 729875Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 729875
[Br:1][C:2]1[CH:3]=[N:4][C:5](F)=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8].[CH2:12]([NH:14][CH2:15][CH3:16])[CH3:13]>C(#N)C>[Br:1][C:2]1[CH:3]=[N:4][C:5]([N:14]([CH2:15][CH3:16])[CH2:12][CH3:13])=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8]

Komponenten

4

Edukt 2

HCID 8021DiethylamineHCID 247213715-Bromo-2-fluoropyridine-3-carboxylic acid

Produkt 1

HCID 597000725-Bromo-2-diethylamino-nicotinic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

880 mg (4.00 mmol) of 5-bromo-2-fluoronicotinic acid was dissolved in 3 ml of acetonitrile. 1.0 ml (9.7 mmol) of diethylamine was added and the resulting mixture heated to 80° C. for 18 h. The mixture was evaporated and the resulting brown oil used without further purification. MS: m/z 273 [MH+].

Aufarbeitung

  1. customThe mixture was evaporated
  2. customthe resulting brown oil used without further purification

Quellen und Nachweise

ORD-Eintrag
ord-137bb328dd0045689c7dc4b92e5adbce
Quelldatensatz
uspto-grants-2009_09
Patentnummer
US07582637B2

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