4-(2-Chloro-pyridin-4-yloxy)-phenylamine → HCID 136183341, Verbindung
Reaktionsgleichung
C(=O)(OC(C)(C)C)[O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[C:13](Cl)[N:12]=[C:11]([NH2:16])[N:10]=2)=[CH:5][CH:4]=1.[NH2:23][C:24]1[CH:37]=[CH:36][C:27]([O:28][C:29]2[CH:34]=[CH:33][N:32]=[C:31]([Cl:35])[CH:30]=2)=[CH:26][CH:25]=1>>[NH2:16][C:11]1[N:10]=[C:9]([C:6]2[CH:5]=[CH:4][C:3]([OH:2])=[CH:8][CH:7]=2)[CH:14]=[C:13]([NH:23][C:24]2[CH:25]=[CH:26][C:27]([O:28][C:29]3[CH:34]=[CH:33][N:32]=[C:31]([Cl:35])[CH:30]=3)=[CH:36][CH:37]=2)[N:12]=1Komponenten
3
Versuchsvorschrift
This material was prepared by a method analogous to that described for Example 1, starting from the product from 4-(2-amino-6-chloropyrimidin-4-yl)phenyl tert-butyl carbonate and Intermediate 2R. 1H NMR (DMSO-d6) δ 9.79 (s, 1H), 9.25 (s, 1H), 8.22 (d, 1H), 7.86 (m, 2H), 7.74 (m, 2H), 7.09 (m, 2H), 6.95 (m, 2H), 6.80 (m, 2H), 6.39 (s, 1H), 6.23 (s, 2H); MS ES 406 (M+H)+, calcd 406, RT=2.74 min.
Aufarbeitung
- customThis material was prepared by a method analogous to