1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine → 4-Chloro-6-trifluoromethyl-2-[4-(3-chloro-5-trifluoromethylpyridin-2-yl)piperazin-1-yl]-1H-benzoimidazole

HRID 730739Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 730739
[Cl:1][C:2]1[C:3]([N:12]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.Cl[C:19]1[NH:23][C:22]2[CH:24]=[C:25]([C:29]([F:32])([F:31])[F:30])[CH:26]=[C:27]([Cl:28])[C:21]=2[N:20]=1>>[Cl:28][C:27]1[C:21]2[N:20]=[C:19]([N:15]3[CH2:16][CH2:17][N:12]([C:3]4[C:2]([Cl:1])=[CH:7][C:6]([C:8]([F:9])([F:10])[F:11])=[CH:5][N:4]=4)[CH2:13][CH2:14]3)[NH:23][C:22]=2[CH:24]=[C:25]([C:29]([F:32])([F:31])[F:30])[CH:26]=1

Komponenten

3

Edukt 2

HCID 6676191-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)piperazineHCID 669373361H-Benzimidazole, 2,7-dichloro-5-(trifluoromethyl)-

Produkt 1

HCID 578350434-Chloro-6-trifluoromethyl-2-[4-(3-chloro-5-trifluoromethylpyridin-2-yl)piperazin-1-yl]-1H-benzoimidazole

Versuchsvorschrift

The reaction of 1-(3-chloro-5-trifluoromethylpyridin-2-yl)piperazine (186 mg, 0.7 mmol, ABCR) and 2,4-dichloro-6-trifluoromethyl-1H-benzoimidazole (127 mg, 0.5 mmol, Example 5b) under the conditions of Example 3c afforded the title compound as a white amorphous solid. MS (ESI, pos. ion) m/z: 484 (M+1).

Quellen und Nachweise

ORD-Eintrag
ord-72fb36abad3c4be0b87444697c8c452a
Quelldatensatz
uspto-grants-2009_09
Patentnummer
US07582761B2

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