2-Methylpiperazine, (R)- → N-{5-Chloro-6-[(3R)-3-methyl-piperazin-1-yl]-pyridin-3-ylmethyl}-acetamide
Reaktionsgleichung
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][NH:10][C:11](=[O:13])[CH3:12])[CH:5]=[N:6][C:7]=1Cl.[CH3:14][C@@H:15]1[CH2:20][NH:19][CH2:18][CH2:17][NH:16]1>>[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][NH:10][C:11](=[O:13])[CH3:12])[CH:5]=[N:6][C:7]=1[N:19]1[CH2:18][CH2:17][NH:16][C@H:15]([CH3:14])[CH2:20]1Komponenten
3
Versuchsvorschrift
A mixture of N-(5,6-dichloro-pyridin-3-ylmethyl)-acetamide from step (d) above (250 mg, 1.14 mmol) and (R)-(−)-2-methyl-piperazine (126 mg, 1.26 mmol, Aldrich) reacted under the conditions of Example 3a to give the title compound. MS (ESI, pos. ion) m/z: 283 (M+1).
Aufarbeitung
- customreacted under the conditions of Example 3a
Quellen und Nachweise
- ORD-Eintrag