Benzyl Bromide → HCID 25228820, Verbindung

HRID 731033Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 731033
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([CH3:11])=[C:5]2[CH3:12].[CH2:13](Br)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>CN(C=O)C>[CH2:13]([N:7]1[C:8]2[C:4](=[CH:3][C:2]([Br:1])=[CH:10][CH:9]=2)[C:5]([CH3:12])=[C:6]1[CH3:11])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Komponenten

4

Edukt 2

HCID 7498Benzyl BromideHCID 127930975-Bromo-2,3-dimethyl-1H-indole

Produkt 1

HCID 25228820HCID 25228820, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

The desired product was prepared using a procedure similar to step 2 of example 3. Thus, 5-bromo-2,3-dimethyl-1H-indole (1.793 g, 8 mmol) was reacted with k-t-butoxide (0.943 g, 8.4 mmol) and benzyl bromide (1.442 g, 8.4 mmol) in DMF (20 ml) to give the product (1.872 g, 5.958 mmol, 74%) as a pink solid. 1H NMR (DMSO-d6) δ 2.18 (s, 3H), 2.26 (s, 3H), 5.38 (s, 21), 6.94 (d, J=7.3 Hz, 2H), 7.12 (dd, J=1.8, 8.6 Hz, 1H), 7.20 (t, J=7.2 Hz, 1H), 7.27 (t, J=7.2 Hz, 2H), 7.32 (d, J=8.7 Hz, 1H), 7.59 (d, J=1.8 Hz, 1H); [EI], m/z 313/315 (M)+.

Quellen und Nachweise

ORD-Eintrag
ord-225bdff290b24a638b3dea8dfc455988
Quelldatensatz
uspto-grants-2009_09
Patentnummer
US07582773B2

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