1-Methyl-1H-pyrrolo[2,3-B]pyridine-5-carbonitrile → HCID 66837868, Verbindung

HRID 73117Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 73117
[CH3:1][N:2]1[C:6]2=[N:7][CH:8]=[C:9]([C:11]#[N:12])[CH:10]=[C:5]2[CH:4]=[CH:3]1>N.CO.[Ni]>[CH3:1][N:2]1[C:6]2=[N:7][CH:8]=[C:9]([CH2:11][NH2:12])[CH:10]=[C:5]2[CH:4]=[CH:3]1

Komponenten

4

Edukt 1

HCID 497588931-Methyl-1H-pyrrolo[2,3-B]pyridine-5-carbonitrile

Produkt 1

HCID 66837868HCID 66837868, VerbindungAusbeute 95,4 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 21705897Ammonia methanolLösungsmittel

Versuchsvorschrift

To a stirred solution of 1-methyl-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile (210 mg, 1.3 mmol) in 10% NH3-MeOH (10 mL) was added Raney Nickel (0.5 mL, Raney (registered trademark) 2800 slurry in water), and the mixture was stirred at room temperature under hydrogen atmosphere for 4 hrs. The mixture was filtered through a pad of Celite (registered trademark), washed with MeOH, the filtrate was concentrated to give 200 mg (93% yield) of the titled compound as a white solid.

Aufarbeitung

  1. filtrationThe mixture was filtered through a pad of Celite (registered trademark)
  2. washwashed with MeOH
  3. concentrationthe filtrate was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-5d5178c71a1742998c0418d7869aba8b
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08829026B2

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